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The synthesis of labelled forms of cipemastat
Author(s) -
Wiltshire H R,
Prior K J,
Dhesi J,
Maile G
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.440
Subject(s) - chemistry , glucuronide , collagenase , amide , in vitro , chemical synthesis , metabolism , stereochemistry , biochemistry , enzyme
The development of the collagenase inhibitor, cipemastat (Ro 32‐3555), required the synthesis of both carbon‐14 labelled and deuteriated material for the measurement of the parent drug and drug‐related material in biological fluids. In addition, labelled metabolites were needed for both in vitro metabolism and analytical studies. This paper describes the synthesis of labelled forms of cipemastat and its amide (Ro 32‐4778) and glucuronide (Ro 32‐6414) metabolites. Copyright © 2001 John Wiley & Sons, Ltd.