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Synthesis of [ N ‐methyl‐ 11 C]mianserin: a tetracyclic, atypical antidepressant
Author(s) -
Marthi K.,
Bender D.,
Smith D.F.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.437
Subject(s) - mianserin , chemistry , methyl iodide , desmethyl , alkylation , in vivo , antidepressant , monoaminergic , stereochemistry , radiochemistry , pharmacology , medicinal chemistry , organic chemistry , biochemistry , serotonin , receptor , endocrinology , catalysis , medicine , microbiology and biotechnology , metabolite , hippocampus , biology
As part of our program to develop PET tracers for investigating monoaminergic processes in the brain, mianserin, a tetracyclic, atypical antidepressant, was selected as a candidate for labelling with 11 C for in vivo evaluation. [ N ‐methyl‐ 11 C]Mianserin was produced by the alkylation of N ‐desmethyl mianserin with [ 11 C]methyl iodide followed by HPLC purification and formulation. [ N ‐methyl‐ 11 C]Mianserin was obtained with a radiochemical purity >93% in a 16% decay corrected radiochemical yield. For a typical production starting with 40 GBq [ 11 C]CO 2 , 1.9 GBq [ N ‐methyl‐ 11 C]mianserin was obtained as a formulated solution in a synthesis time of 35 min (counted from EOB). Copyright © 2001 John Wiley & Sons, Ltd.