Radioiodinated α 1 ‐adrenergic receptor ligands | Zendy

Hamill Terence G. | Zendy; Burns H. Donald | Zendy; Gibson Raymond E. | Zendy

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Radioiodinated α 1 ‐adrenergic receptor ligands

Author(s) -

Hamill Terence G.,

Burns H. Donald,

Gibson Raymond E.

Publication year - 2001

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.433

Subject(s) - prazosin , chemistry , receptor , adrenergic receptor , stereochemistry , adrenergic , biochemistry , antagonist

The synthesis and preliminary characterization of three radioiodinated α 1 ‐adrenergic receptor ligands [ 125 I] 5a–c are described. These tracers are analogs of L‐760,478, 1b , itself an analog of prazosin, 1a . The highest affinity tracer, [ 125 I] 5a , has six fold higher affinity for the α 1 receptor subtypes than prazosin. These ligands could be useful for autoradiographic studies of the α 1 receptor subtypes. Copyright © 2001 John Wiley & Sons, Ltd.

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