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Radioiodinated α 1 ‐adrenergic receptor ligands
Author(s) -
Hamill Terence G.,
Burns H. Donald,
Gibson Raymond E.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.433
Subject(s) - prazosin , chemistry , receptor , adrenergic receptor , stereochemistry , adrenergic , biochemistry , antagonist
The synthesis and preliminary characterization of three radioiodinated α 1 ‐adrenergic receptor ligands [ 125 I] 5a–c are described. These tracers are analogs of L‐760,478, 1b , itself an analog of prazosin, 1a . The highest affinity tracer, [ 125 I] 5a , has six fold higher affinity for the α 1 receptor subtypes than prazosin. These ligands could be useful for autoradiographic studies of the α 1 receptor subtypes. Copyright © 2001 John Wiley & Sons, Ltd.