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Syntheses of 2 H‐labelled dihydropyrimidinediones and their metabolites
Author(s) -
Heinkele Georg,
Hofmann Ute,
Opitz Joachim,
Mürdter Thomas E.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.426
Subject(s) - chemistry , uracil , thymine , radiochemistry , catalysis , metabolite , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , dna
Starting with uracil or thymine, [5,5,6,6‐ 2 H 4 ]‐dihydrouracil and [5,6,6,α,α,α,‐ 2 H 6 ]‐dihydrothymine were synthesised in high yields by catalytic deuteriation. Subsequent hydrolyses resulted in the corresponding β‐ureidoalkanoic acids and β‐aminoacids. Copyright © 2001 John Wiley & Sons, Ltd.