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Preparation and biological evaluation of radioiodine‐labeled triphenylphosphine derivatives as mitochondrial targeting probes
Author(s) -
Shi Shuyu,
Liu Zelan,
Wu Zhenmin,
Zhou Hang,
Lu Jie
Publication year - 2021
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3910
Subject(s) - chemistry , triphenylphosphine , radiochemistry , combinatorial chemistry , organic chemistry , catalysis
The positive‐charged lipophilic triphenylphosphonium cations (TPPs + ) have been served as mitochondrial targeting vehicles for the delivery of various probes. In this study, we developed a new method for the preparation of radioiodine‐labeled TPPs + . Four 125 I‐labeled TPPs + , [ 125 I] 9–[ 125 I] 12 , were prepared from the corresponding triphenylphosphine phenylborate precursors of B 5–B 8 via an optimized copper‐catalyzed one‐step procedure in high radiochemical yield (>95%). After radio‐HPLC purification, the final products could be obtained with high specific activity. Their physicochemical properties, in vitro cellular uptake, and ex vivo mice biodistribution were investigated. The results suggested the 125 I‐labeled TPPs + were lipophilic and could specifically accumulate in the mitochondrial‐rich myocardial cells through the mitochondrial membrane potential.