Synthesis of [4 S ‐ 2 H]NADH, [4 R ‐ 2 H]NADH, [4‐ 2 H 2 ]NADH and [4‐ 2 H]NAD +  cofactors through heterogeneous biocatalysis in heavy water | Zendy

Rowbotham Jack S. | Zendy; Hardy Adam P. | Zendy; Reeve Holly A. | Zendy; Vincent Kylie A. | Zendy

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Synthesis of [4 S ‐ 2 H]NADH, [4 R ‐ 2 H]NADH, [4‐ 2 H 2 ]NADH and [4‐ 2 H]NAD + cofactors through heterogeneous biocatalysis in heavy water

Author(s) -

Rowbotham Jack S.,

Hardy Adam P.,

Reeve Holly A.,

Vincent Kylie A.

Publication year - 2021

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3899

Subject(s) - chemistry , cofactor , nad+ kinase , deuterium , nicotinamide , kinetic isotope effect , stereochemistry , nicotinamide adenine dinucleotide , enzyme , biochemistry , physics , quantum mechanics

This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4 S ‐ 2 H]NADH, [4 R ‐ 2 H]NADH, [4‐ 2 H 2 ]NADH and [4‐ 2 H]NAD + . The application of a recently developed H 2 ‐driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2 H‐incorporation with 2 H 2 O as the only isotope source.

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