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Automated radiosynthesis of [ 68 Ga]Ga‐PSMA‐11 and [ 177 Lu]Lu‐PSMA‐617 on the iPHASE MultiSyn module for clinical applications
Author(s) -
Wichmann Christian W.,
Ackermann Uwe,
Poniger Stan,
Young Kenneth,
Nguyen Benjamin,
Chan Gordon,
Sachinidis John,
Scott Andrew M.
Publication year - 2021
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3889
Subject(s) - radiosynthesis , chemistry , radiochemistry , nuclear medicine , positron emission tomography , medicine
Prostate‐specific membrane antigen (PSMA)‐targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly changing clinical practice. To facilitate clinical trials, fully automated procedures for the radiosyntheses of [ 68 Ga]Ga‐PSMA‐11 and [ 177 Lu]Lu‐PSMA‐617 were developed from commercially available precursors using the cassette based iPHASE MultiSyn module. Formulated and sterile radiopharmaceuticals were obtained in 76 ± 3% ( n = 20) and 91 ± 4% ( n = 15) radiochemical yields after 17 and 20 min, respectively. Radiochemical purity was always >95% and molar activities exceeded 792 ± 100 and 88 ± 6 GBq/μmol, respectively. Quality control showed conformity with all relevant release criteria and radiopharmaceuticals were used in the clinic.