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Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5‐[ 18 F]fluoro‐L‐amino suberate
Author(s) -
Alluri Santosh R.,
Pitman Kathinka E.,
Malinen Eirik,
Riss Patrick J.
Publication year - 2020
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3814
Subject(s) - radiosynthesis , positron emission tomography , chemistry , neurodegeneration , neuroimaging , pet imaging , radiochemistry , amino acid , tracer , nuclear medicine , biochemistry , neuroscience , pathology , psychology , medicine , nuclear physics , physics , disease
System xc‐ (Sx c ‐) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sx c ‐ ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sx c ‐ PET tracer 5[18F]fluoro‐L‐amino suberate by manual and automated radiosyntheses are described. A brain‐PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.