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Recent advances in iridium(I) catalysis towards directed hydrogen isotope exchange
Author(s) -
Kerr William J.,
Knox Gary J.,
Paterson Laura C.
Publication year - 2020
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3812
Subject(s) - iridium , chemistry , catalysis , phosphine , carbene , combinatorial chemistry , scope (computer science) , substrate (aquarium) , nanotechnology , organic chemistry , materials science , computer science , oceanography , geology , programming language
The initial discovery and establishment of a family of novel iridium catalysts possessing N ‐heterocyclic carbene units alongside bulky phosphine ligands allowed selected substrates to be labelled using deuterium or tritium gas at desirably low catalyst loadings via an ortho ‐directed C―H insertion process. Such a method has broad applicability and offers distinct advantages within the pharmaceutical industry, directly facilitating the ability to carefully monitor a potential drug molecule's biological fate. Over the past decade since these initial protocols were divulged, many additional advances have been made in terms of catalyst design and substrate scope. This review describes the broadened array of new iridium catalysts and associated protocols for direct and selective C―H activation and hydrogen isotope insertion within a number of new chemical entities of direct relevance to the pharmaceutical industry.