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Highlights of C (sp 2 )–H hydrogen isotope exchange reactions
Author(s) -
Hesk David
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3801
Subject(s) - chemistry , catalysis , hydrogen isotope , hydrogen , solvent , selectivity , radiochemistry , inorganic chemistry , organic chemistry
The highlights of C (sp 2 )–H hydrogen isotope exchange (HIE) methods developed over the past 10 years are summarized in this review. Major developments include improved Ir(I) catalysts with greater functional group and solvent compatibility and the development of novel base metal catalysts for HIE. In addition, a number of novel Ru‐based catalysts have been developed with promising activity. In the area of Pt‐ and Pd‐catalysed exchange, in addition to new advances on heterogeneous Pt‐ and Pd‐catalysed HIE by Sajiki and Shevchenko, a number of groups have reported on homogenous catalysts of Pt and Pd that show an interesting activity and selectivity.