Synthesis of [ 13 C 2,   15 N]‐1,3‐2 H ‐1‐benzyl‐( Z )‐3‐(benzylidene)indolin‐2‐one | Zendy

Yang Jixia | Zendy; Zhang Gongzheng | Zendy; Wang Zhaoyang | Zendy; Xiao Zhanxiong | Zendy; Wen Hongliang | Zendy

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Synthesis of [ 13 C 2, 15 N]‐1,3‐2 H ‐1‐benzyl‐( Z )‐3‐(benzylidene)indolin‐2‐one

Author(s) -

Yang Jixia,

Zhang Gongzheng,

Wang Zhaoyang,

Xiao Zhanxiong,

Wen Hongliang

Publication year - 2019

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3796

Subject(s) - chemistry , chloroacetic acid , mass spectrometry , aniline , microsome , stereochemistry , nuclear chemistry , organic chemistry , chromatography , enzyme

Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α‐synuclein into Lewy bodies. 3‐Benzylidine‐indolin‐2‐one represents a class of compounds, which are known to inhibit the accumulation of α‐synuclein. In this paper, we report the synthesis of [ 13 C] and [ 15 N] labelled 1‐benzyl‐( Z )‐3‐(benzylidene)indolin‐2‐one from commercially available [ 13 C 2 ]‐chloroacetic acid and [ 15 N]‐aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography‐tandem mass spectrometry.

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