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Synthesis of [ 13 C 2, 15 N]‐1,3‐2 H ‐1‐benzyl‐( Z )‐3‐(benzylidene)indolin‐2‐one
Author(s) -
Yang Jixia,
Zhang Gongzheng,
Wang Zhaoyang,
Xiao Zhanxiong,
Wen Hongliang
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3796
Subject(s) - chemistry , chloroacetic acid , mass spectrometry , aniline , microsome , stereochemistry , nuclear chemistry , organic chemistry , chromatography , enzyme
Parkinson disease (PD) is a neurodegenerative disorder characterized by the accumulation of α‐synuclein into Lewy bodies. 3‐Benzylidine‐indolin‐2‐one represents a class of compounds, which are known to inhibit the accumulation of α‐synuclein. In this paper, we report the synthesis of [ 13 C] and [ 15 N] labelled 1‐benzyl‐( Z )‐3‐(benzylidene)indolin‐2‐one from commercially available [ 13 C 2 ]‐chloroacetic acid and [ 15 N]‐aniline in five steps. The product will be used to study its metabolites in human liver microsomes by liquid chromatography‐tandem mass spectrometry.