Premium
A convenient synthesis of the muscarinic cholinergic antagonist (R)‐[N‐methyl‐ 3 H]quinuclidinyl benzilate methiodide
Author(s) -
Filer Crist N.,
Seguin Richard J.
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3775
Subject(s) - methiodide , chemistry , quinuclidinyl benzilate , muscarinic acetylcholine receptor , antagonist , muscarinic antagonist , stereochemistry , cholinergic , biochemistry , neuroscience , receptor , psychology
A useful synthesis of ( R )‐[N‐methyl‐ 3 H]quinuclidinyl benzilate methiodide is described with the product characterized by thin‐layer chromatography (TLC), high‐performance liquid chromatography (HPLC), tritium nuclear magnetic resonance (NMR), and mass spectrometry (MS). Several methods are provided to purify the radioligand, and its storage and stability are also discussed.