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Automated production of [ 68 Ga]Ga‐DOTANOC and [ 68 Ga]Ga‐PSMA‐11 using a TRACERlab FX FN synthesis module
Author(s) -
GarciaArguello Segundo Francisco,
LopezLorenzo Beatriz,
RuizCruces Rafael
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3706
Subject(s) - chemistry , gallium , piperazine , elution , radiochemistry , nuclear chemistry , sodium , chromatography , organic chemistry
The interest in gallium‐68 labelled positron‐emission tomography probes continues to increase around the world. However, one of the barriers for routine clinical use is the cost of the automated synthesis units for relatively simple labelling procedures. Herein, we describe the adaptation of a TRACERlab FX FN synthesis module for the automated production of gallium‐68 radiopharmaceuticals using a cation‐exchange cartridge for postprocessing of the 68 Ge/ 68 Ga generator eluate. The recovery of activity from the cartridge was 95.6% to 98.9% using solutions of acidified sodium chloride (5 M with pH = 1‐3). The radiosyntheses of [ 68 Ga]Ga‐DOTANOC and [ 68 Ga]Ga‐PSMA‐11 were performed using acetate sodium buffer or 4‐(2‐hydroxyethyl)piperazine‐1‐ethanesulfonic acid, with a total duration of 21 and 23 minutes, respectively, including generator elution and radiopharmaceutical dispensing. Activity yields were 77% ± 2% for [ 68 Ga]Ga‐PSMA‐11 and 68% ± 3% for [ 68 Ga]Ga‐DOTANOC (n > 100). The labelled peptides had a radiochemical purity exceeding 97%, and all quality control parameters were in conformity with the limits prescribed by the European Pharmacopoeia.