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New radical methods for the potential synthesis of carbon‐13 and carbon‐14 labeled complex products
Author(s) -
Maxwell Brad D.
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3680
Subject(s) - chemistry , carbon fibers , molecule , isotopes of carbon , radical , carbon 14 , combinatorial chemistry , organic chemistry , total organic carbon , materials science , physics , quantum mechanics , composite number , composite material
The isotopic labeling of molecules for agrichemical and pharmaceutical uses is becoming more challenging as molecules become larger, involve more stereochemistry, and as intellectual property rights become more complex. As such, isotope chemists need to continually add new isotopic methods to their armamentarium to successfully label complex molecules with carbon‐13 and carbon‐14. Recently, there has been a surge in the use of radicals to form new carbon‐carbon bonds and for the incorporation of functional groups which can be used to incorporate isotopically labeled carbons. This review will describe some potential new radical methods for incorporating isotopically labeled carbon into complex molecules or into substrates that can be attached to late stage intermediates to generate labeled products.