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Radiosynthesis and validation of [ Carboxy ‐ 11 C]4‐ A minobenzoic acid ([ 11 C ] PABA ), a PET radiotracer for imaging bacterial infections
Author(s) -
Holt Daniel P.,
Kalinda Alvin S.,
Bambarger Lauren E.,
Jain Sanjay K.,
Dannals Robert F.
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3674
Subject(s) - chemistry , radiosynthesis , specific activity , yield (engineering) , radiochemistry , mole , molar ratio , nuclear chemistry , chromatography , catalysis , enzyme , biochemistry , nuclear medicine , positron emission tomography , medicine , materials science , metallurgy
In this practitioner protocol, the radiochemical synthesis of [ 11 C] PABA is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (14% at end‐of‐synthesis (EOS)) at high specific activity (molar activity 11 Ci/μmole EOS; 407 GBq/μmole) and high chemical and radiochemical purity as a sterile, pyrogen‐free solution suitable for injection conforming to current Good Manufacturing Practice (cGMP) requirements.