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An efficient synthesis of trace amine‐associated receptor agonist [1‐ 14 C]tyramine
Author(s) -
Filer Crist N.,
Orphanos Demetri
Publication year - 2019
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3671
Subject(s) - chemistry , tyramine , hydrochloride , agonist , amine gas treating , high performance liquid chromatography , phenethylamine , chemical synthesis , trace amounts , chromatography , combinatorial chemistry , organic chemistry , stereochemistry , receptor , biochemistry , in vitro , medicine , alternative medicine , pathology
The 2‐step synthesis of [1‐ 14 C]tyramine hydrochloride is described with the product being characterized by TLC, HPLC, and UV spectroscopy. Several methods are provided to purify [1‐ 14 C]tyramine hydrochloride, and its storage and stability are also discussed.