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Synthesis of carbon‐14 labeled ZJ0712, a novel strobilurin fungicide
Author(s) -
Yang ZhengMin,
Xu YaJun,
Zhang GuiHua,
Jian CaiGuang,
Li Xiao,
Ye QingFu
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3646
Subject(s) - chemistry , strobilurin , fungicide , yield (engineering) , residue (chemistry) , phenol , carbon 14 , broad spectrum , medicinal chemistry , organic chemistry , stereochemistry , horticulture , combinatorial chemistry , azoxystrobin , materials science , physics , quantum mechanics , metallurgy , biology
ZJ0712, a broad‐spectrum fungicidal ingredient of strobilurin, exhibits a high protective and curative activity against plant pathogenic fungi. To support the study on its metabolism, residue, environmental behavior, and fate for safety evaluation, two versions of carbon‐14 labeled ZJ0712, methyl ( E )‐2‐(2‐((2,5‐dimethylphenoxy)methyl)phenyl)‐3‐methoxy[2‐ 14 C]acrylate ( 2 ) and methyl ( E )‐2‐(2‐((2,5‐dimethyl[ phenyl ‐U‐ 14 C 6 ]phenoxy)methyl)phenyl)‐3‐methoxyacrylate ( 3 ), were synthesized from barium [ 14 C]carbonate in 6‐step yield of 47% and from 2,5‐dimethyl[ phenyl ‐U‐ 14 C 6 ]phenol in the yield of 91%, respectively.