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An efficient and facile synthesis of deuterium‐labeled anticancer agent bendamustine hydrochloride
Author(s) -
Liu Baomin,
Qin Hui,
Zhang Yinsheng
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3637
Subject(s) - bendamustine , chemistry , hydrochloride , deuterium , radiochemistry , organic chemistry , lymphoma , medicine , rituximab , physics , quantum mechanics
Bendamustine hydrochloride is an alkylating agent that was developed for the treatment of various human cancers. The stable isotope‐labeled bendamustine was required to support clinic studies. An effective and operationally simple method for the synthesis of [D 6 ] bendamustine hydrochloride was developed using DCl as a catalyst and D 2 O as a deuterium source. Under the present condition, regioselectively deuterated bendamustine hydrochloride with high deuterium incorporation is achieved.