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Generation and use of tritiated borane in situ for formamide tritiation to an N‐methyl‐ 3 H group
Author(s) -
Nugent Richard P.,
Filer Crist N.
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3624
Subject(s) - tritium , formamide , chemistry , in situ , mass spectrometry , radiochemistry , thin layer chromatography , borane , methyl group , chromatography , group (periodic table) , organic chemistry , catalysis , nuclear physics , physics
The synthesis of [N‐methyl‐ 3 H](+/−)‐mecamylamine is described as an example of a convenient and mild method to reduce formamide groups using tritiated borane generated in situ. The product was characterized by thin layer chromatography, high performance liquid chromatography, mass spectrometry, and tritium NMR.