An optimized radiosynthesis of [ 18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH) | Zendy

Azad Babak Behnam | Zendy; Holt Daniel P. | Zendy; Ravert Hayden T. | Zendy; Horti Andrew G. | Zendy; Dannals Robert F. | Zendy

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An optimized radiosynthesis of [ 18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH)

Author(s) -

Azad Babak Behnam,

Holt Daniel P.,

Ravert Hayden T.,

Horti Andrew G.,

Dannals Robert F.

Publication year - 2018

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3620

Subject(s) - radiosynthesis , chemistry , positron emission tomography , radiochemistry , pet imaging , epoxide hydrolase , positron , epoxide , nuclear chemistry , nuclear medicine , nuclear physics , enzyme , organic chemistry , electron , physics , catalysis , microsome , medicine

In this concise practitioner protocol, the radiochemical synthesis of [ 18 F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.

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