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An optimized radiosynthesis of [ 18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH)
Author(s) -
Azad Babak Behnam,
Holt Daniel P.,
Ravert Hayden T.,
Horti Andrew G.,
Dannals Robert F.
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3620
Subject(s) - radiosynthesis , chemistry , positron emission tomography , radiochemistry , pet imaging , epoxide hydrolase , positron , epoxide , nuclear chemistry , nuclear medicine , nuclear physics , enzyme , organic chemistry , electron , physics , catalysis , microsome , medicine
In this concise practitioner protocol, the radiochemical synthesis of [ 18 F]FNDP suitable for human positron emission tomography studies is described and the results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice requirements.