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Evaluation of a P,N ‐ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds
Author(s) -
Valero Mégane,
Burhop Annina,
Jess Kristof,
Weck Remo,
Tamm Matthias,
Atzrodt Jens,
Derdau Volker
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3595
Subject(s) - chemistry , iridium , catalysis , hydrogen isotope , aryl , deuterium , hydrogen , kinetic isotope effect , isotope , hydrogen–deuterium exchange , radiochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , alkyl , physics , quantum mechanics
We have developed a novel and efficient iridium‐catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient temperatures. Furthermore N ‐oxides and phosphonamides have been successfully applied in hydrogen isotope exchange reactions with moderate to excellent deuterium introduction.