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The vial kit formulation for preparation of no‐carrier‐added 131 I‐MIBG
Author(s) -
Chen Zhiming,
Wang Gang,
Xie Minhao,
Huang Heyun,
Wu Erming,
Wang Yang
Publication year - 2018
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3539
Subject(s) - biodistribution , chemistry , vial , specific activity , radiochemistry , chromatography , biochemistry , enzyme , in vitro
We have developed a new set of lyophilized kits, composed of 3 different kits, for the instant preparation of no‐carrier‐added 131 I‐MIBG in the clinic. We here discussed the formulation of the kits, optimization of radiolabelling, quality control of radiolabeled 131 I‐MIBG, and studies of animal biodistribution. The no‐carrier‐added (nca) 131 I‐MIBG injection could be prepared within 30 minutes in the clinic with the help of the lyophilized kits. The radiochemical purity and specific activity (SA) could achieve above 98% and 6700 MBq/mg, respectively.