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An updated synthesis of [ 11 C]carfentanil for positron emission tomography (PET) imaging of the μ‐opioid receptor
Author(s) -
Blecha Joseph E.,
Henderson Bradford D.,
Hockley Brian G.,
VanBrocklin Henry F.,
Zubieta JonKar,
DaSilva Alexandre F.,
Kilbourn Michael R.,
Koeppe Robert A.,
Scott Peter J.H.,
Shao Xia
Publication year - 2017
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3513
Subject(s) - chemistry , cartridge , positron emission tomography , radiosynthesis , pet imaging , carboxylate , radiochemistry , extraction (chemistry) , opioid receptor , nuclear medicine , nuclear chemistry , opioid , chromatography , receptor , stereochemistry , biochemistry , medicine , mechanical engineering , engineering
[ 11 C]Carfentanil ([ 11 C]CFN) is a selective radiotracer for in vivo positron emission tomography imaging studies of the μ‐opioid system that, in our laboratories, is synthesized by methylation of the corresponding carboxylate precursor with [ 11 C]MeOTf, and purified using a C2 solid‐phase extraction cartridge. Changes in the commercial availability of common C2 cartridges have necessitated future proofing the synthesis of [ 11 C]CFN to maintain reliable delivery of the radiotracer for clinical imaging studies. An updated synthesis of [ 11 C]CFN is reported that replaces a now obsolete purification cartridge with a new commercially available version and also substitutes the organic solvents used in traditional production methods with ethanol.