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Automated synthesis of N ‐(2‐[ 18 F]Fluoropropionyl)‐ l ‐glutamic acid as an amino acid tracer for tumor imaging on a modified [ 18 F]FDG synthesis module
Author(s) -
Liu Shaoyu,
Sun Aixia,
Zhang Zhanwen,
Tang Xiaolan,
Nie Dahong,
Ma Hui,
Jiang Shende,
Tang Ganghua
Publication year - 2017
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3505
Subject(s) - chemistry , glutamic acid , tracer , amino acid , radiochemistry , biochemistry , nuclear physics , physics
N ‐(2‐[ 18 F]Fluoropropionyl)‐ l ‐glutamic acid ([ 18 F]FPGLU) is a potential amino acid tracer for tumor imaging with positron emission tomography. However, due to the complicated multistep synthesis, the routine production of [ 18 F]FPGLU presents many challenging laboratory requirements. To simplify the synthesis process of this interesting radiopharmaceutical, an efficient automated synthesis of [ 18 F]FPGLU was performed on a modified commercial fluorodeoxyglucose synthesizer via a 2‐step on‐column hydrolysis procedure, including 18 F‐fluorination and on‐column hydrolysis reaction. [ 18 F]FPGLU was synthesized in 12 ± 2% (n = 10, uncorrected) radiochemical yield based on [ 18 F]fluoride using the tosylated precursor 2 . The radiochemical purity was ≥98%, and the overall synthesis time was 35 minutes. To further optimize the radiosynthesis conditions of [ 18 F]FPGLU, a brominated precursor 3 was also used for the preparation of [ 18 F]FPGLU, and the improved radiochemical yield was up to 20 ± 3% ( n = 10, uncorrected) in 35 minutes. Moreover, all these results were achieved using the similar on‐column hydrolysis procedure on the modified fluorodeoxyglucose synthesis module.