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Enantiospecific tritium labeling of 28‐homocastasterone
Author(s) -
Elbert Tomáš,
Patil Mahadeo R.,
Marek Aleš
Publication year - 2017
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3488
Subject(s) - tritium , chemistry , yield (engineering) , tritium illumination , radiochemistry , specific activity , catalysis , chemical synthesis , nuclear chemistry , organic chemistry , in vitro , biochemistry , nuclear physics , enzyme , materials science , physics , metallurgy
A regiospecific and enantiospecific synthesis of tritium‐labeled 28‐homocastasterone is reported. Appropriate chlorocarbonate, efficiently synthesized from the starting 28‐homocastasterone in an overall yield of 46%, undergoes catalytic tritium dechlorination by the T 2 /Pd[0]/Et 3 N system, providing 28‐[3β‐ 3 H]homocastasterone, in a good yield, radiochemical purity (>97%), and with a high specific activity (5.8 Ci/mmol).
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