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Buscopan labeled with carbon‐14 and deuterium
Author(s) -
Latli Bachir,
Stiasni Michael,
Hrapchak Matt,
Li Zhibin,
Grinberg Nelu,
Lee Heewon,
Busacca Carl A.,
Senanayake Chris H.
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3463
Subject(s) - chemistry , bromide , deuterium , anticholinergic , carbon 14 , moiety , carbon fibers , radiochemistry , organic chemistry , medicinal chemistry , nuclear chemistry , pharmacology , medicine , physics , materials science , composite material , quantum mechanics , composite number
Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon‐14– and deuterium‐labeled Buscopan was developed using scopolamine, n ‐butyl‐1‐ 14 C bromide, and n ‐butyl‐ 2 H 9 bromide, respectively. In a second carbon‐14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety to follow its metabolism. Herein, we describe the detailed preparations of carbon‐14– and deuterium‐labeled Buscopan.