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Efficient synthesis of D 6 ‐clenproperol and D 6 ‐cimaterol using deuterium isopropylamine as labelled precursor
Author(s) -
Sun Kai,
Fang Chao,
Yang Weicheng,
Xu Zhongjie,
Wang Haoran,
Sun Wen,
Luo Yong,
Xu Yi
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3447
Subject(s) - chemistry , isopropylamine , deuterium , natural abundance , mass spectrometry , abundance (ecology) , radiochemistry , isotope , chromatography , organic chemistry , nuclear physics , physics , fishery , biology
This report presents an efficient synthesis of D 6 ‐clenproperol and D 6 ‐cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor. Their structures and the isotope‐abundance were confirmed by proton nuclear magnetic resonance and liquid chromatography–mass spectrometry.

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