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Synthesis of stable isotope labeled D 9 ‐Mabuterol, D 9 ‐Bambuterol, and D 9 ‐Cimbuterol
Author(s) -
Tu Yahui,
Zhong Jiaqi,
Wang Haoran,
Pan Jie,
Xu Zhongjie,
Yang Weicheng,
Luo Yong
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3446
Subject(s) - chemistry , isotope , natural abundance , stable isotope ratio , abundance (ecology) , mass spectrometry , chromatography , radiochemistry , tandem , nuclear physics , physics , biology , materials science , fishery , composite material
Three stable and simple synthetic routes of labeled D 9 ‐Mabuterol, D 9 ‐Bambuterol, and D 9 ‐Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope‐abundance were confirmed according to 1 H NMR and liquid chromatography‐tandem mass spectrometry.