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An improved synthesis of the radiolabeled prostate‐specific membrane antigen inhibitor, [ 18 F]DCFPyL
Author(s) -
Ravert Hayden T.,
Holt Daniel P.,
Chen Ying,
Mease Ronnie C.,
Fan Hong,
Pomper Martin G.,
Dannals Robert F.
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3430
Subject(s) - chemistry , radiosynthesis , yield (engineering) , specific activity , glutamate carboxypeptidase ii , radiochemistry , combinatorial chemistry , nuclear medicine , organic chemistry , enzyme , prostate , positron emission tomography , medicine , materials science , cancer , metallurgy
The radiosynthesis of [ 18 F]DCFPyL on 2 distinct automated platforms with full regulatory compliant quality control specifications is described. The radiotracer synthesis was performed on a custom‐made radiofluorination module and the Sofie Biosciences ELIXYS. The radiofluorination module synthesis was accomplished in an average of 66 minutes from end of bombardment with an average specific activity at end of synthesis (EOS) of 4.4 TBq/μmol (120 Ci/μmol) and an average radiochemical yield of 30.9% at EOS. The ELIXYS synthesis was completed in an average of 87 minutes with an average specific activity of 2.2 TBq/μmol (59.3 Ci/μmol) and an average radiochemical yield of 19% at EOS. Both synthesis modules produced large millicurie quantities of [ 18 F]DCFPyL while conforming to all standard US Pharmacopeia Chapter <823> acceptance testing criteria.