Premium
Fully automated synthesis of [ 18 F]fluoro‐dihydrotestosterone ([ 18 F]FDHT) using the FlexLab module
Author(s) -
Ackermann Uwe,
Lewis Jason S.,
Young Kenneth,
Morris Michael J.,
Weickhardt Andrew,
Davis Ian D.,
Scott Andrew M.
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3417
Subject(s) - chemistry , dihydrotestosterone , combinatorial chemistry , biochemistry , hormone , androgen
Imaging of androgen receptor expression in prostate cancer using F‐18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [ 18 F] FDHT is important. We have fully automated the synthesis of F‐18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25‐33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up‐scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost‐effective. The synthesis has now been validated at Austin Health and is currently used for [ 18 F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [ 18 F]FDHT.