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An easy and effective method for synthesis and radiolabelling of risedronate as a model for bone imaging
Author(s) -
Motaleb M. A.,
Adli A. S. A.,
ElTawoosy M.,
Sanad M. H.,
AbdAllah M.
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3384
Subject(s) - chemistry , biodistribution , yield (engineering) , radiochemistry , bone imaging , pet imaging , technetium , nuclear chemistry , nuclear medicine , biochemistry , in vitro , positron emission tomography , medicine , materials science , metallurgy
This study aimed to provide an easy method for synthesis of 1‐hydroxy‐2‐(3‐pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) with a high yield of 71%. The synthesized risedronate was labeled with technetium‐99 m using two different reducing agents (SnCl 2 .2H 2 O and NaBH 4 ) where NaBH 4 gave stable complex and higher radiochemical yield more than SnCl 2 .2H 2 O. The results showed that, the radiochemical purity of 99m Tc(NaBH 4 )‐risedronate was 99.2 ± 0.6% and its stability was up to 6 h. Biodistribution study showed high uptake and long retention of 99m Tc(NaBH 4 )‐risedronate in bone starting from 15 min (29 ± 2.5% ID/organ) up to 4 h (35.1 ± 3.2 ID/organ) post injection. This research could introduce an easy and effective method for synthesis and labeling of risedrionate and affording a good tracer for bone imaging.