Synthesis of 2‐(methylsulfonyl)‐5‐(4‐(methylsulfonyl) phenyl)‐4‐phenyl‐1H‐[5‐ 14 C]imidazole, a selective COX‐2 inhibitor, via asymmetrical benzoins | Zendy

Shirvani Gholamhossein | Zendy; Shockravi Abbas | Zendy; Amini Mohsen | Zendy; Saemian Nader | Zendy

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Synthesis of 2‐(methylsulfonyl)‐5‐(4‐(methylsulfonyl) phenyl)‐4‐phenyl‐1H‐[5‐ 14 C]imidazole, a selective COX‐2 inhibitor, via asymmetrical benzoins

Author(s) -

Shirvani Gholamhossein,

Shockravi Abbas,

Amini Mohsen,

Saemian Nader

Publication year - 2016

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3382

Subject(s) - chemistry , imidazole , potassium cyanide , ring (chemistry) , cyanide , stereochemistry , medicinal chemistry , stereoselectivity , organic chemistry , catalysis

4,5‐Diarylimidazoles labeled with carbon‐14 in the 5‐position of the imidazole ring were prepared as a part of three‐step sequence from 2‐hydroxy‐1‐(4‐(methylthio)phenyl)‐2‐phenyl[1‐ 14 C]ethanone as a key synthetic intermediate which has been synthesized from potassium [ 14 C]cyanide.

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