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Synthesis of 2‐(methylsulfonyl)‐5‐(4‐(methylsulfonyl) phenyl)‐4‐phenyl‐1H‐[5‐ 14 C]imidazole, a selective COX‐2 inhibitor, via asymmetrical benzoins
Author(s) -
Shirvani Gholamhossein,
Shockravi Abbas,
Amini Mohsen,
Saemian Nader
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3382
Subject(s) - chemistry , imidazole , potassium cyanide , ring (chemistry) , cyanide , stereochemistry , medicinal chemistry , stereoselectivity , organic chemistry , catalysis
4,5‐Diarylimidazoles labeled with carbon‐14 in the 5‐position of the imidazole ring were prepared as a part of three‐step sequence from 2‐hydroxy‐1‐(4‐(methylthio)phenyl)‐2‐phenyl[1‐ 14 C]ethanone as a key synthetic intermediate which has been synthesized from potassium [ 14 C]cyanide.