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Production and characterization of 166 Ho polylactic acid microspheres
Author(s) -
Yavari Kamal,
Yeganeh Ehsan,
Abolghasemi Hossein
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3366
Subject(s) - polylactic acid , microsphere , irradiation , chemistry , scanning electron microscope , particle size , particle (ecology) , nuclear chemistry , in vivo , radiochemistry , chemical engineering , materials science , composite material , polymer , organic chemistry , physics , oceanography , microbiology and biotechnology , nuclear physics , engineering , biology , geology
Microsphere and particle technology with selective transport of radiation represents a new generation of therapeutics. Poly‐ L ‐lactic acid (PLLA) microspheres loaded with holmium‐166 acetylacetonate ( 166 Ho‐PLLA‐MS) are novel microdevices. In this research, 165 HoAcAc‐PLLA microparticles were prepared by the solvent evaporation technique. Microspheres were irradiated at Tehran Research Reactor. The diameter and surface morphologies were characterized by particle sizer and scanning electron microscopy before and after irradiation. The complex stability, radiochemical purity, and in vivo biodistribiotion were checked in the final solution up to 3 days. In this study, 166 Ho‐PLLA spherical particles with a smooth surface and diameter of 20–40 µm were obtained, which were stable in vitro and in vivo studies. Neutron irradiation did not damage the particles. The ease with which the PLLA spheres could be made in the optimal size range for later irradiation and their ability to retain the 166 Ho provided good evidence for their potential use in radioembolization.