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In vitro and in vivo evaluation of technetium‐99m‐labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers
Author(s) -
Zhang Qiang,
Huang Huafan,
Chu Taiwei
Publication year - 2016
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3365
Subject(s) - nitroimidazole , chemistry , oxime , in vivo , in vitro , redox , amine gas treating , biodistribution , nitro , stereochemistry , hypoxia (environmental) , combinatorial chemistry , biochemistry , oxygen , organic chemistry , alkyl , microbiology and biotechnology , biology
Hypoxia markers have been the subject of intensive research in radiopharmaceuticals, but there is little work on markers with multi‐redox centers. It is necessary to further develop and investigate the compounds containing multi‐redox centers systematically. Two propylene amine oxime ligands, compound 1, containing 3‐nitro‐1,2,4‐triazole and 4‐nitroimidazole and compound 2, containing 3‐nitro‐1,2,4‐triazole and 2‐nitroimidazole were synthesized and radiolabeled with 99m Tc; then these complexes were also evaluated in vitro and in vivo . Some comparisons were made with the other complexes of our previous work, and some interesting conclusions were obtained. 99m Tc‐1 and 99m Tc‐2 displayed significant hypoxic/normoxic differentials in both S180 and H22 cell lines. These complexes held moderate tumor‐to‐blood and tumor‐to‐muscle ratios, indicating they might serve as novel hypoxia markers. Some comparisons showed the in vitro evaluation may be connected with the number and the type of the redox centers, and the biodistribution experiments may have relation with the hydrophilicity and the type of redox centers.