Premium
Improving the 18 F‐fluoromethylcholine ( 18 F‐FCH) radiochemical yield via optimising the azeotropic drying of non‐carrier‐added 18 F‐fluorine
Author(s) -
Hassan Hishar,
Abu Bakar Suharzelim,
Che A. Halim Khairul Najah,
Idris Jaleezah,
Ahmad Saad Fathinul Fikri,
Nordin Abdul Jalil
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3347
Subject(s) - chemistry , yield (engineering) , radiochemistry , fluorine , nuclear chemistry , organic chemistry , physics , thermodynamics
18 F‐Fluoromethylcholine ( 18 F‐FCH) has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in PET/CT examination. Nevertheless, it has never been synthesised in Malaysia. We acknowledged the major problem with 18 F‐FCH is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this technical note presents improved 18 F‐FCH radiochemical yields after carrying out optimisation on azeotropic drying of non‐carrier‐added 18 F‐Fluorine.