Synthesis of [ 2 H 6 ]ceftazidime as a stable isotopically labeled internal standard | Zendy

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Synthesis of [ 2 H 6 ]ceftazidime as a stable isotopically labeled internal standard

Author(s) -

Bian Lei,

Bushby Nick

Publication year - 2015

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3290

Subject(s) - ceftazidime , chemistry , cephalosporin , escherichia coli , cephalosporin antibiotic , isobutyric acid , pseudomonas aeruginosa , gram , enterobacteriaceae , isotope , antibiotics , chromatography , bacteria , organic chemistry , biochemistry , genetics , gene , biology , physics , quantum mechanics

Ceftazidime is a third generation cephalosporin antibiotic that has activity against a wide range of Gram‐negative and Gram‐positive bacterial pathogens, including Escherichia coli and Pseudomonas aeruginosa . Stable isotope‐labeled ceftazidime was required for use as an internal standard in LC‐MS/MS assays, and a route was developed to make [ 2 H 6 ]ceftazidime in eight steps from the commercially available labeled starting material [ 2 H 7 ]isobutyric acid.

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