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Synthesis of [ 2 H 6 ]ceftazidime as a stable isotopically labeled internal standard
Author(s) -
Bian Lei,
Bushby Nick
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3290
Subject(s) - ceftazidime , chemistry , cephalosporin , escherichia coli , cephalosporin antibiotic , isobutyric acid , pseudomonas aeruginosa , gram , enterobacteriaceae , isotope , antibiotics , chromatography , bacteria , organic chemistry , biochemistry , genetics , gene , biology , physics , quantum mechanics
Ceftazidime is a third generation cephalosporin antibiotic that has activity against a wide range of Gram‐negative and Gram‐positive bacterial pathogens, including Escherichia coli and Pseudomonas aeruginosa . Stable isotope‐labeled ceftazidime was required for use as an internal standard in LC‐MS/MS assays, and a route was developed to make [ 2 H 6 ]ceftazidime in eight steps from the commercially available labeled starting material [ 2 H 7 ]isobutyric acid.