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Investigating the pharmacokinetics and biological distribution of silver‐loaded polyphosphoester‐based nanoparticles using 111 Ag as a radiotracer
Author(s) -
Aweda Tolulope A.,
Zhang Shiyi,
Mupanomunda Chiedza,
Burkemper Jennifer,
Heo Gyu Seong,
Bandara Nilantha,
Lin Mai,
Cutler Cathy S.,
Can Carolyn L.,
Youngs Wiley J.,
Wooley Karen L.,
Lapi Suzanne E.
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3289
Subject(s) - biodistribution , pharmacokinetics , chemistry , in vivo , nuclear chemistry , silver nanoparticle , radiochemistry , pharmacology , nanoparticle , in vitro , materials science , nanotechnology , medicine , biochemistry , microbiology and biotechnology , biology
Purified 111 Ag was used as a radiotracer to investigate silver loading and release, pharmacokinetics, and biodistribution of polyphosphoester‐based degradable shell crosslinked knedel‐like (SCK) nanoparticles as a comparison to the previously reported small molecule, N ‐heterocyclic silver carbene complex analog (SCC1) for the delivery of therapeutic silver ions in mouse models. Biodistribution studies were conducted by aerosol administration of 111 Ag acetate, [ 111 Ag]SCC1, and [ 111 Ag]SCK doses directly into the lungs of C57BL/6 mice. Nebulization of the 111 Ag antimicrobials resulted in an average uptake of 1.07 ± 0.12% of the total aerosolized dose given per mouse. The average dose taken into the lungs of mice was estimated to be 2.6 ± 0.3% of the dose inhaled per mouse for [ 111 Ag]SCC1 and twice as much dose was observed for the [ 111 Ag]SCKs (5.0 ± 0.3% and 5.9 ± 0.8% for [ 111 Ag]aSCK and [ 111 Ag]zSCK, respectively) at 1 h post administration (p.a.). [ 111 Ag]SCKs also exhibited higher dose retention in the lungs; 62–68% for [ 111 Ag]SCKs and 43% for [ 111 Ag]SCC1 of the initial 1 h dose were observed in the lungs at 24 h p.a.. This study demonstrates the utility of 111 Ag as a useful tool for monitoring the pharmacokinetics of silver‐loaded antimicrobials in vivo .