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Current radiosynthesis strategies for 5‐HT 2A receptor PET tracers
Author(s) -
Herth Matthias M.,
Knudsen Gitte M.
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3288
Subject(s) - radiosynthesis , positron emission tomography , chemistry , 5 ht receptor , serotonin , tracer , pet imaging , neuroimaging , receptor , neuroscience , psychology , biochemistry , physics , nuclear physics
Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5‐HT 2A R positron emission tomography‐tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5‐HT 2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.