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No‐carrier‐added labeling of the neuroprotective Ebselen with selenium‐73 and selenium‐75
Author(s) -
Helfer Andreas,
Ermert Johannes,
Humpert Sven,
Coenen Heinz H.
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3274
Subject(s) - ebselen , selenium , chemistry , positron emission tomography , radiochemistry , positron , nuclear medicine , organic chemistry , nuclear physics , antioxidant , medicine , catalase , physics , glutathione peroxidase , electron
Selenium‐73 is a positron emitting non‐standard radionuclide, which is suitable for positron emission tomography. A copper‐catalyzed reaction allowed no‐carrier‐added labeling of the anti‐inflammatory seleno‐organic compound Ebselen with 73 Se and 75 Se under addition of sulfur carrier in a one‐step reaction. The new authentically labeled radioselenium molecule is thus available for preclinical evaluation and positron emission tomography studies.