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Synthesis of a [ 14 C]‐steroid intermediate: an application of a nonstabilized Horner–Wadsworth–Emmons olefination approach
Author(s) -
Rivera Nelo R.,
Ren Sumei,
Hesk David
Publication year - 2015
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3257
Subject(s) - chemistry , steroid , derivative (finance) , reactivity (psychology) , unavailability , organic chemistry , stereochemistry , medicinal chemistry , biochemistry , medicine , alternative medicine , pathology , hormone , financial economics , reliability engineering , economics , engineering
Radiolabeled steroid derivative 1 was successfully prepared using a Horner–Wadsworth–Emmons approach: a [ 14 C]‐label was efficiently incorporated into the C‐18 position of the molecule. Previously published procedures employing other olefination methods are either not applicable due to unavailability of [ 14 C]‐precursors or suffer from poor reactivity.