Synthesis of a [ 14 C]‐steroid intermediate: an application of a nonstabilized Horner–Wadsworth–Emmons olefination approach | Zendy

Rivera Nelo R. | Zendy; Ren Sumei | Zendy; Hesk David | Zendy

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Synthesis of a [ 14 C]‐steroid intermediate: an application of a nonstabilized Horner–Wadsworth–Emmons olefination approach

Author(s) -

Rivera Nelo R.,

Ren Sumei,

Hesk David

Publication year - 2015

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3257

Subject(s) - chemistry , steroid , derivative (finance) , reactivity (psychology) , unavailability , organic chemistry , stereochemistry , medicinal chemistry , biochemistry , medicine , alternative medicine , pathology , hormone , financial economics , reliability engineering , economics , engineering

Radiolabeled steroid derivative 1 was successfully prepared using a Horner–Wadsworth–Emmons approach: a [ 14 C]‐label was efficiently incorporated into the C‐18 position of the molecule. Previously published procedures employing other olefination methods are either not applicable due to unavailability of [ 14 C]‐precursors or suffer from poor reactivity.

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