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Synthesis of [ 2 H 7 ]indatraline
Author(s) -
Allmendinger L.,
Wanner K. T.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3245
Subject(s) - chemistry , friedel–crafts reaction , benzene , reagent , alkylation , moiety , deuterium , solvent , aryl , molecule , organic chemistry , catalysis , alkyl , physics , quantum mechanics
Deuterium‐labelled indatraline was synthesized in high efficiency employing a Friedel–Crafts alkylation of [ 2 H 6 ]benzene with ( E )‐3‐(3,4‐dichlorophenyl)acrylic acid as a key step. The desired labelling of the final compound was ascertained in two ways, by incorporation of [ 2 H 6 ]benzene in the target molecule and additionally by deuterium transfer to the non‐deuterated aryl moiety of the Friedel–Crafts alkylation product from [ 2 H 6 ]benzene, the latter thus serving as reagent and solvent.