Premium
A new [ 2 H]‐labelled α ‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates
Author(s) -
Heinkele Georg,
Geditz Mirjam C. K.,
Ganchev Boian,
Kerb Reinhold,
Hofmann Ute,
Mürdter Thomas E.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3243
Subject(s) - chemistry , glucuronic acid , conjugate , deuterium , glucuronates , radiochemistry , organic chemistry , stereochemistry , polysaccharide , nuclear physics , mathematical analysis , physics , mathematics
A new reaction pathway for the synthesis of a [ 2 H]‐labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope‐labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.