A new [ 2 H]‐labelled  α ‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates | Zendy

Heinkele Georg | Zendy; Geditz Mirjam C. K. | Zendy; Ganchev Boian | Zendy; Kerb Reinhold | Zendy; Hofmann Ute | Zendy; Mürdter Thomas E. | Zendy

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A new [ 2 H]‐labelled α ‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates

Author(s) -

Heinkele Georg,

Geditz Mirjam C. K.,

Ganchev Boian,

Kerb Reinhold,

Hofmann Ute,

Mürdter Thomas E.

Publication year - 2014

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3243

Subject(s) - chemistry , glucuronic acid , conjugate , deuterium , glucuronates , radiochemistry , organic chemistry , stereochemistry , polysaccharide , nuclear physics , mathematical analysis , physics , mathematics

A new reaction pathway for the synthesis of a [ 2 H]‐labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope‐labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.

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