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Synthesis of [ 18 O 2 ]‐curcumin
Author(s) -
Shen Xiurui,
Yang Xiaomei,
Zhu Ying,
Liu Xihuan,
Wen Hongliang
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3238
Subject(s) - curcumin , curcuma , chemistry , rhizome , yield (engineering) , pharmacology , stereochemistry , combinatorial chemistry , biochemistry , traditional medicine , medicine , materials science , metallurgy
Curcumin, a pigment isolated from rhizomes of Curcuma longa , is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [ 18 O 2 ]‐curcumin. [ 18 O 2 ]‐Curcumin was prepared in three steps from 1‐iodo‐2‐methoxy‐4‐methylbenzene in an overall yield of 53%.