Syntheses of [ 14 C]‐labeled 2‐(3‐chlorophenyloxy)‐3‐[3‐(3‐hydroxy) pyridin‐4‐yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites | Zendy

Ochi Takeshi | Zendy; Sawayama Yusuke | Zendy; Kawasaki Motoji | Zendy; Nigo Tomohiro | Zendy; Nakao Masashi | Zendy; Omodani Tomoki | Zendy; Sumiyoshi Takaaki | Zendy

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Syntheses of [ 14 C]‐labeled 2‐(3‐chlorophenyloxy)‐3‐[3‐(3‐hydroxy) pyridin‐4‐yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites

Author(s) -

Ochi Takeshi,

Sawayama Yusuke,

Kawasaki Motoji,

Nigo Tomohiro,

Nakao Masashi,

Omodani Tomoki,

Sumiyoshi Takaaki

Publication year - 2014

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3211

Subject(s) - chemistry , pyridine , phosphodiesterase , yield (engineering) , phosphodiesterase inhibitor , stereochemistry , carbon 14 , medicinal chemistry , enzyme , organic chemistry , biochemistry , materials science , metallurgy , physics , quantum mechanics

We describe here the synthesis of [ 14 C]‐2‐(3‐chlorophenyloxy)‐3‐[3‐(3‐hydroxy)pyridin‐4‐yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [ 14 C]‐Labeled 1 was prepared in three steps from [ 14 C]‐2‐bromopyridin‐3‐ol in an overall yield of 32%. Preparation of [ 14 C]‐labeled 2 and 3, two metabolites of 1, is also described. Copyright © 2014 John Wiley & Sons, Ltd.

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