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Syntheses of [ 14 C]‐labeled 2‐(3‐chlorophenyloxy)‐3‐[3‐(3‐hydroxy) pyridin‐4‐yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites
Author(s) -
Ochi Takeshi,
Sawayama Yusuke,
Kawasaki Motoji,
Nigo Tomohiro,
Nakao Masashi,
Omodani Tomoki,
Sumiyoshi Takaaki
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3211
Subject(s) - chemistry , pyridine , phosphodiesterase , yield (engineering) , phosphodiesterase inhibitor , stereochemistry , carbon 14 , medicinal chemistry , enzyme , organic chemistry , biochemistry , materials science , metallurgy , physics , quantum mechanics
We describe here the synthesis of [ 14 C]‐2‐(3‐chlorophenyloxy)‐3‐[3‐(3‐hydroxy)pyridin‐4‐yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [ 14 C]‐Labeled 1 was prepared in three steps from [ 14 C]‐2‐bromopyridin‐3‐ol in an overall yield of 32%. Preparation of [ 14 C]‐labeled 2 and 3, two metabolites of 1, is also described. Copyright © 2014 John Wiley & Sons, Ltd.