A simple method for  α ‐position deuterated carbonyl compounds with pyrrolidine as catalyst | Zendy

Zhan Miao | Zendy; Zhang Tao | Zendy; Huang Haoxi | Zendy; Xie Yongmei | Zendy; Chen Yuanwei | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A simple method for α ‐position deuterated carbonyl compounds with pyrrolidine as catalyst

Author(s) -

Zhan Miao,

Zhang Tao,

Huang Haoxi,

Xie Yongmei,

Chen Yuanwei

Publication year - 2014

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3210

Subject(s) - pyrrolidine , chemistry , catalysis , cyclohexene , deuterium , hydrolysis , hydrogen–deuterium exchange , organic chemistry , medicinal chemistry , hydrogen , physics , quantum mechanics

A simple, cost‐effective method for deuteration of carbonyl compounds employing pyrrolidine as catalyst and D 2 O as deuterium source was described. High degree of deuterium incorporation (up to 99%) and extensive functional group tolerance were achieved. It is the first time that secondary amines are used as catalysts for H/D exchange of carbonyl compounds, which also allow the deuteration of complex pharmaceutically interesting substrates. A possible catalytic mechanism, based on the hydrolysis of 1‐pyrrolidino‐1‐cyclohexene, for this pyrrolidine‐catalyzed H/D exchange reaction has been proposed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research