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Radiochemical synthesis of 2′‐[ 18 F]‐labelled and 3′‐[ 18 F]‐labelled nucleosides for positron emission tomography imaging
Author(s) -
Meyer JanPhilip,
Probst Katrin C.,
Westwell Andrew D.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3197
Subject(s) - positron emission tomography , chemistry , radiochemistry , pet imaging , nucleoside , positron , nuclear medicine , medical physics , physics , nuclear physics , stereochemistry , electron , medicine
This review article considers 2′‐labelled and 3′‐labelled nucleosides, which are of great importance as positron emission tomography (PET) probes in clinical diagnostics and PET research. Although the radiochemical preparation of several [ 18 F]‐labelled nucleosides such as [ 18 F]fluorothymidine or [ 18 F](fluoroarabinofuranosyl)cytosine has been accomplished within the last two decades, a number of potentially interesting nucleoside‐based biomarkers are not yet available for automated good manufacturing practice production due to the lack of fast and efficient synthetic methods for late‐stage [ 18 F]‐introduction. In order to meet recent demands for new PET‐based biomarkers in various clinical applications, appropriate precursors that can easily be fluorinated and deprotected need to be developed.