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A short expedient synthesis of [ 14 C]Ticlopidine
Author(s) -
Hickey Michael J.,
Kingston Lee P.,
Allen Paul H.,
Johnson Tim,
Wilkinson David J.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3184
Subject(s) - chemistry , metabolite , ticlopidine , chemical synthesis , molecule , hydrochloride , nuclear chemistry , ethanol , radiochemistry , stereochemistry , organic chemistry , in vitro , biochemistry , aspirin , clopidogrel
To support the development of a reactive metabolite strategy, the preparation of several radiolabelled compounds such as [ 14 C] Ticlopidine was required. In this report, we describe a facile and rapid synthesis of [ 14 C] Ticlopidine starting from [ 14 C] carbon dioxide. The compound was radiolabelled in the 2‐chloromethyl portion of the molecule with a specific activity of 53.4 mCi/mmol and with a radiochemical purity of 98.5%. Storage stability was best as the hydrochloride salt in an ethanol solution. Copyright © 2014 John Wiley & Sons, Ltd.
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