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Radiolabelled porphyrins in nuclear medicine
Author(s) -
Waghorn Philip A.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3166
Subject(s) - porphyrin , chemistry , photodynamic therapy , hematoporphyrin , combinatorial chemistry , cancer research , pharmacology , biochemistry , computational biology , organic chemistry , medicine , biology
Amongst tumour‐specific substances, hematoporphyrin and synthetic porphyrin derivatives have been widely investigated to identify and delineate neoplastic and malignant tissue. Whilst the tumour localization exhibited by selected porphyrin species has been exploited through photodynamic therapy, several examples of porphyrin derivatives with varied peripheral functionality have been radiolabelled with the aim of developing porphyrin‐based nuclear imaging and therapeutic agents. In this review, we look at the approaches and advances in the preparation and uses of such radiolabelled agents for imaging and therapy. Copyright © 2013 John Wiley & Sons, Ltd.