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Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals
Author(s) -
Cai Zhengxin,
Anderson Carolyn J.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3165
Subject(s) - chemistry , copper , chelation , positron emission tomography , biomolecule , radiochemistry , conjugated system , in vivo , radionuclide , nanotechnology , nuclear medicine , inorganic chemistry , biochemistry , organic chemistry , materials science , nuclear physics , polymer , medicine , physics , microbiology and biotechnology , biology
The development of chelating agents for copper radionuclides in positron emission tomography radiopharmaceuticals has been a highly active and important area of study in recent years. The rapid evolution of chelators has resulted in highly specific copper chelators that can be readily conjugated to biomolecules and efficiently radiolabeled to form stable complexes in vivo . Chelators are not only designed for conjugation to monovalent biomolecules but also for incorporation into multivalent targeting ligands such as theranostic nanoparticles. These advancements have strengthened the role of copper radionuclides in the fields of nuclear medicine and molecular imaging. This review emphasizes developments of new copper chelators that have most greatly advanced the field of copper‐based radiopharmaceuticals over the past 5 years.