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Prospects for enhancement of targeted radionuclide therapy of cancer using ultrasound
Author(s) -
Browning Richard J.,
Rajkumar Vineeth,
Pedley R. Barbara,
Eckersley Robert J.,
Blower Philip J.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3157
Subject(s) - radioimmunotherapy , medicine , ultrasound , drug delivery , distribution (mathematics) , cancer therapy , cancer , targeted therapy , targeted drug delivery , medical physics , cancer research , drug , monoclonal antibody , pharmacology , antibody , radiology , nanotechnology , immunology , materials science , mathematical analysis , mathematics
Ultrasound‐mediated drug delivery is a promising means of enhancing delivery, distribution and effectiveness of drugs within tumours. In this review, prospects for exploiting ultrasound to improve the tumour delivery and distribution of radiolabelled antibodies for radioimmunotherapy and to overcome barriers imposed by tumour microenvironment are discussed. Copyright © 2013 John Wiley & Sons, Ltd.